A couple months back Outlook 2007 started asking if I wanted to save changes when I would close out of the program. I could not put my finger on the change(s) that were made to my system to prompt the start of such behavior. Finally after a couple months of putting up with it I did some googling and while I did not find a direct (acceptable) answer to my problem I did find a user that had a similar problem where an add-in was to blame. They suggested that it was Adobe. Given that I do not need the add-in integration in Outlook, I disabled that along with a bunch of others. That seemed to do the trick.
To disable add-ins open Outlook 2007 as an administrator and then go to Tools>Trust Center>Add-ins. Down at the bottom, you will see a drop down that is titled ‘Manage’. Choose COM Add-ins and select Go. From there you can uncheck the items you want to disable. Some add-ins require admin privileges to disable but it will let you know if you forgot step 1 (run as admin).
Hope this helps someone else.
UPDATE: DAMN YOU OUTLOOK!!! STOP ASKING ME!!!!